Histological section of a diseased human heart.

Cardiac Epigenetics and Epigenomics

Our lab makes use of genomic technologies and molecular epigenetic approaches to explore new mechanisms of disease in the heart.

Heart Failure is characterized by a hallmark change in gene expression programmes. Epigenetics or chromatin modulations may, therefore, be the means by which myriad initiating causes are integrated to produce the final common pathway of heart failure.

Heart failure is the final common pathway for disparate initiating causes of cardiovascular disease.

  • Mortality of heart failure is ~50% in 5 years, rivaling that of even some cancers.
  • Heart failure incidence is increasing with an ever aging world population.
  • New treatment options for heart failure are urgently needed.
Global Burden of Heart Failure (from Savarese and Lund, 2017)

It's finally made it... genetic variants discovered through the epigenome and interactome maps of the heart @lekwen90 @Meekelee @shyam_lab @TheFooLab @CvdNus @NUSMedicine #epigenetics #epigenome #heartfailure #chromatin @3D_Genome @CircRes

Kick off to Day 1 post-circuit breaker and reopening here in Singapore! An evening of fascinating work and sharing by @PorrelloER and his team. A great pleasure to catch up on good science and we still have more questions!

#cvd #cardiacregeneration #SingleCell


Thanks to @rsyf2 for inviting to speak at NUHS @NUSingapore Clinical Scientist Academy Seminars. It was pure pleasure to interact with Clinician scientists and specially discussions on application of scRNA-seq in clinic.. #ShowMustGoOnline

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