Histological section of a diseased human heart.

Cardiac Epigenetics and Epigenomics

Our lab makes use of genomic technologies and molecular epigenetic approaches to explore new mechanisms of disease in the heart.

Heart Failure is characterized by a hallmark change in gene expression programmes. Epigenetics or chromatin modulations may, therefore, be the means by which myriad initiating causes are integrated to produce the final common pathway of heart failure.

Heart failure is the final common pathway for disparate initiating causes of cardiovascular disease.

  • Mortality of heart failure is ~50% in 5 years, rivaling that of even some cancers.
  • Heart failure incidence is increasing with an ever aging world population.
  • New treatment options for heart failure are urgently needed.
Global Burden of Heart Failure (from Savarese and Lund, 2017)

Great way to spend the evening with Professor Nadia Rosenthal speak to us about #regenerative_medicine . Apart from talking about missing the cocktails in #Singapore @CvdNus @TheFooLab @astar_research @NUSMedicine

Featuring our work on identifying disease-causing genetic variants and genes #HiChIP @rsyf2 @lekwen90. Finally putting them all together in one piece, our cover was featured in the august issue of @CircRes, cover image rendered with #rhino3d @Meekelee.
https://doi.org/10.1161/CIRCRESAHA.120.317254

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