Research Projects

Clinical Genomics

Clinical Genomics

  Clinical genomics is advancing the diagnostic rate for human genetic diseases, and continues to unravel novel genotype and phenotype...

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Chromatin architecture & Cardiac epigenetics

Chromatin architecture & Cardiac epigenetics

The genome is folded into a 3-dimensional conformation in the tight nuclear space. In this project, we are working to unravel how the dynamics of...

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Circular RNA

Circular RNA

Circular RNAs (circRNAs) are a class of non-coding, single-stranded RNA, circularized as a result of back-splicing, and therefore lacking the...

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Long non-coding RNA

Long non-coding RNA

A complex landscape of transcription exists across the non-coding genome, promising the further discovery of novel epigenetic regulators involved...

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Cell States, Regeneration, Differentiation & Dedifferentiation

Cell States, Regeneration, Differentiation & Dedifferentiation

Our lab is making use of the human pluripotent stem cells derived cardiomyocytes (hPSC-CM) system, and leveraging our experience with Genomic and...

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Cell-Cell Communication

Cell-Cell Communication

The mammalian heart is an organ comprising of heterogeneous cell types. In this project, we are exploring mechanisms by which diverse cellular...

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High-throughput Screening

High-throughput Screening

In this project, we are working closely with the Centre of High Throughput Phenomics (CHiP) at the Genome Institute, which is a valuable shared...

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Technical capabilities

Clinical Genomics

Next Generation Sequencing technology allows us to sequence whole human genomes to look for...

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Bioinformatics & Computational Biology

Projects in our lab revolve critically around bioinformatic analysis and integration of...

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Engineered Heart Tissue

The generation of 3D cell-based miniature Engineered Heart Tissue (EHT) (Hansen, Eder et...

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In vivo models of disease

In vivo models of heart disease are central to Foo lab research. Any adequate study of the...

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CRISPR/CAS9 Genome Editing

The Foo lab uses CRISPR/Cas9 tools in different ways, both in vitro & in vivo. We do...

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Viruses

The Foo lab relies heavily on the Adeno-associated viruses (AAV) platform for in vivo gene...

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Histology

Our studies with mouse and human hearts frequently require detailed histological...

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RNA-Seq

RNA-seq is the next-generation sequencing based technique that we use to analyse global...

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Human Embryonic Stem Cell Differentiation

In the Foo lab, we are continuously generating hES-derived cardiomyocytes as an in-vitro...

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Single Cell Technologies

The adult mammalian heart is made up of complex heterogeneous cell types...

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Hi-C

Chromosome capture conformation with high throughput sequencing (Hi-C) is the molecular...

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ChIP-Seq

Chromatin Immunoprecipitation (ChIP) combined with Next-Gen Sequencing is the method of...

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Funding Support

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