In vivo models of disease
In vivo models of heart disease is central to Foo lab research. Any adequate study of the mammalian heart has to be performed in the context of a live animal. Rodents are the ideal model for in vivo studies of the heart. Our lab has established robust and consistent surgical models of disease (Transverse Aortic Constriction, Myocardial Infarction, and pharmacological models by minipump-based drug delivery). Phenotype is assessed through a variety of imaging modalities including Ultrasound (echocardiography), PET-Scan, MRI and LV cath. Supported by the animal facility at NUS, the team has also conducted metabolic studies involving exercise related equipment.
The animal team, led by Peter, is also responsible to comply with strict regulatory and safety protocols, established by local regulatory bodies AVA, IACUC and NUS. The team works within the framework from AAALAC and is supported by the vets and support staff from Comparative Medicine, NUS. At the current time, the lab is maintaining at least 19 transgenic/knockout mouse strains. We have experience importing mice from Jacksons Lab, Invivos, Charles River and other research institutes around the world.