Cell States, Regeneration, Differentiation & Dedifferentiation Previous item Long non-coding RNA Next item Cell-Cell Communication

Cell States, Regeneration, Differentiation & Dedifferentiation

Our lab is making use of the human pluripotent stem cells derived cardiomyocytes (hPSC-CM) system, and leveraging our experience with Genomic and Epigenetic analyses to study cell states and gene expression programmes in the different stages of cardiac development and disease pathophysiology. A key objective in these projects is to discover central molecular epigenetic “switches” that may be responsible for modulating gene expression programmes in the heart. These “switches” may represent targets for the next generation of treatment for heart disease.

20
20

 

Differentiation and de-differentiation

Differentiation
20
De-differentiation
Adult mouse cardiomyocytes (CMs) cultured in vitro breakdown and re-build their sarcomeres (Ackers-Johnson, et al. Circ Res 119.8 (2016): 909-920.).
20

Add Your Comment

Your email address will not be published. Required fields are marked *

Style switcher RESET
Body styles
Background pattern
Background image