Circular RNAs (circRNAs) are a class of non-coding, single-stranded RNA, circularized as a result of back-splicing, and therefore lack the traditional 5’cap and 3’ poly-A tail. We1 and others2 have described the expression landscape of circRNA in mouse and human hearts. However, the functional relevance of many of these abundantly expressed cardiomyocyte circRNA remains to be fully explored. Among the most abundant circRNA, one arises from the sodium-calcium exchanger gene, Slc8a1, exon 2 locus. Because of its very high abundance in cardiomyocytes we have investigated the role of circSlc8a1 in the heart. Independently, we are also exploring the use of synthetic circRNA as a new approach for gene therapy.
Circles in the heart and cardiovascular system. Cardiovasc Res. 2019.
A landscape of circular RNA expression in the human heart. Cardiovasc Res, 2017.
Lave, Benson, Matt.