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Circular RNA

Circular RNAs (circRNAs) are a class of non-coding, single-stranded RNA, circularized as a result of back-splicing, and therefore lack the traditional 5’cap and 3’ poly-A tail. We1 and others2 have described the expression landscape of circRNA in mouse and human hearts. However, the functional relevance of many of these abundantly expressed cardiomyocyte circRNA remains to be fully explored. Among the most abundant circRNA, one arises from the sodium-calcium exchanger gene, Slc8a1, exon 2 locus. Because of its very high abundance in cardiomyocytes we have investigated the role of circSlc8a1 in the heart. Independently, we are also exploring the use of synthetic circRNA as a new approach for gene therapy.

 

Reducing the circular RNA, circSlc8a1, in cardiomyocytes attenuates pressure-overload induced hypertrophy.
Abundance of circular RNAs correlate well with the expression level of their linear gene counterparts
There are a total of 10 and 17 potential binding sites for miR-133 in mouse and human circSLC8A1, respectively, compared to 3 and 1 potential binding sites for miR-1 in mouse and human circSLC8A1, respectively.

 

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