Long non-coding RNA
A complex landscape of transcription exists across the non-coding genome, promising the further discovery of novel epigenetic regulators involved in important biological processes including cardiac specification and maturation, as well as the control of disease and healthy cardiac cell states. Other than transcription factors and chromatin modifiers, long non-coding RNAs (lncRNA) have gained attention as important modulators of cardiac cell biology and pathophysiology.
Our lab is making use of established robust differentiation and trans-differentiation protocols, as well as experimental disease models, and studying the transcriptome datasets to uncover new lncRNAs involved in cardiac development and disease. Candidates from these may represent new therapeutic approaches for heart disease in the future.