David Charles Klinzing

PhD (Tufts, Boston MA)

Senior Research Fellow

Email: mdckdc(at)nus.edu.sg

David is a molecular biologist and computation biologist with many years of experience in research, academia and biotechnology. David was part of one of the first genome projects – the E. coli genome project at the University of Wisconsin – as an undergraduate and has done extensive DNA sequencing, genomics and computational work over his career. After receiving his PhD from Tufts University in the US, David worked as a computer programmer before completing a post-doctoral stint at Harvard Medical School. David moved to the Philippines in 2009 and supported the introduction of next generation sequencing to the country, as well as teaching that the university graduate school. David moved to Singapore in 2013 to join the biotechnology company AITbiotech, where he was directly involved in the next generation sequencing business of AITbiotech which ultimately spun off as a joint venture with Novogene of China to form NovogeneAIT in Singapore. David helped establish the human whole genome sequencing laboratory of NovogeneAIT which is involved in the SG10K 10,000 genomes project and David also led the set up of NovogeneAIT biocomputing resources in Singapore.  David is involved in many aspects of the bioinformatics work in the Foo Lab including population genomics analysis, clinical genomics, data visualization and data management.

Education and Experience

B.S. – Genetics. University of Wisconsin – Madison USA. 1989

PhD – Biology. Tufts University – Boston MA. 1997

Research Fellow in Medicine. Harvard Medical School. 2004-2009.

Assistant Professor of Biology. Ateneo de Manila University. Manila Philippines. 2009-2010.

Assistant Professor I. St. Luke’s College of Medicine – MS in Molecular Medicine Program. Quezon City Philippines. 2010-2013.

Laboratory Director – AITbiotech and NovogeneAIT. Singapore. 2013-2018.

Publications

1: Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Chien JY, Hsueh PR, Dick T. Draft Genome Sequence of Mycobacterium avium 11. Genome Announc. 2017 Aug 10;5(32). pii: e00766-17. doi: 10.1128/genomeA.00766-17. PubMed PMID: 28798178; PubMed Central PMCID: PMC5552987.

2: Roa MB, Liles VR, Torres BC, Klinzing DC, Lagamayo E, Navoa-Ng J, Daroy MLG. Draft Whole-Genome Assemblies of Drug-Resistant Clinical Isolates of Klebsiella pneumoniae from the Philippines. Genome Announc. 2017 Jul 13;5(28). pii: e00475-17. doi: 10.1128/genomeA.00475-17. PubMed PMID: 28705960; PubMed Central PMCID: PMC5511899.

3: Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Dick T. Draft Genome Sequence of  Mycobacterium abscessus Bamboo. Genome Announc. 2017 May 18;5(20). pii: e00388-17. doi: 10.1128/genomeA.00388-17. PubMed PMID: 28522728; PubMed Central PMCID: PMC5477336.

4: Salvoza NC, Klinzing DC, Gopez-Cervantes J, Baclig MO. Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease. PLoS One. 2016 Apr 14;11(4):e0153497. doi: 10.1371/journal.pone.0153497. eCollection 2016. PubMed PMID: 27077736; PubMed Central PMCID: PMC4831793.

5: Chou A, Roa M, Evangelista MA, Sulit AK, Lagamayo E, Torres BC, Klinzing DC, Daroy ML, Navoa-Ng J, Sucgang R, Zechiedrich L. Emergence of Klebsiella pneumoniae ST273 Carrying bla(NDM-7) and ST656 Carrying bla(NDM-1) in Manila, Philippines. Microb Drug Resist. 2016 Oct;22(7):585-588. Epub 2016 Mar 31. PubMed PMID: 27032000; PubMed Central PMCID: PMC5073224.

6: Klinzing DC, Choi SY, Hasan NA, Matias RR, Tayag E, Geronimo J, Skowronski E,  Rashed SM, Kawashima K, Rosenzweig CN, Gibbons HS, Torres BC, Liles V, Alfon AC,  Juan ML, Natividad FF, Cebula TA, Colwell RR. Hybrid Vibrio cholerae El Tor lacking SXT identified as the cause of a cholera outbreak in the Philippines. mBio. 2015 Apr 21;6(2). pii: e00047-15. doi: 10.1128/mBio.00047-15. PubMed PMID:  25900650; PubMed Central PMCID: PMC4453562.

7: Kawashima KD, Suarez LA, Labayo HK, Liles VR, Salvoza NC, Klinzing DC, Daroy ML, Matias RR, Natividad FF. Complete genome sequence of chikungunya virus isolated in the Philippines. Genome Announc. 2014 Jun 26;2(3). pii: e00336-14. doi: 10.1128/genomeA.00336-14. PubMed PMID: 24970822; PubMed Central PMCID: PMC4073106.

8: Klinzing DC, Ishmael N, Hotopp JCD, Tettelin H, Shields KR, Madoff LC, Puopolo KM. The two-component response regulator LiaR regulates cell wall stress responses, pili expression and virulence in group B Streptococcus. Microbiology.  2013 Jul;159(Pt 7):1521-1534. doi: 10.1099/mic.0.064444-0. Epub 2013 May 23. PubMed PMID: 23704792; PubMed Central PMCID: PMC3749725.

9: Klinzing DC, Matias RR, Skowronski E, Alvarez M, Liles V, Dimamay MP, Natividad FF. Shotgun genome sequence of a Yersinia enterocolitica isolate from the Philippines. J Bacteriol. 2012 Jan;194(2):542-3. doi: 10.1128/JB.06451-11. PubMed PMID: 22207747; PubMed Central PMCID: PMC3256663.

10: Klinzing DC, Madoff LC, Puopolo KM. Genomic analysis identifies a transcription-factor binding motif regulating expression of the alpha C protein in Group B Streptococcus. Microb Pathog. 2009 Jun;46(6):315-20. doi: 10.1016/j.micpath.2009.03.003. Epub 2009 Mar 27. PubMed PMID: 19328843; PubMed Central PMCID: PMC2747082.

11: Puopolo KM, Klinzing DC, Lin MP, Yesucevitz DL, Cieslewicz MJ. A composite transposon associated with erythromycin and clindamycin resistance in group B Streptococcus. J Med Microbiol. 2007 Jul;56(Pt 7):947-955. doi: 10.1099/jmm.0.47131-0. PubMed PMID: 17577061.

12: Godin RE, Klinzing DC, Porcaro WA, Ernst SG. Specification of endoderm in the sea urchin embryo. Mech Dev. 1997 Sep;67(1):35-47. PubMed PMID: 9347913.

13: Soltysik-Española M, Klinzing DC, Pfarr K, Burke RD, Ernst SG. Endo16, a large multidomain protein found on the surface and ECM of endodermal cells during sea urchin gastrulation, binds calcium. Dev Biol. 1994 Sep;165(1):73-85. PubMed PMID: 8088452.

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